Bone marrow-derived mesenchymal stem cells, the nature and uses of their differentiation.

This report investigates the cytokine expression during osteogenic and stromal differentiation of human mesenchymal stem cells (MSCs) from bone marrow. Their conclusions: “Primary and osteogenic differentiated MSCs produce important hematopoietic cytokines and support hematopoiesis in long-term cultures, suggesting that these cells may provide an excellent ex vivo environment for hematopoiesis during progenitor cell expansion and may be important for in vivo cell therapy.”